{'_ty': ['FLA'], '_au': ['Uraguchi, D.', 'Yamamoto, K.', 'Ohtsuka, Y.', 'Tokuhisa, K.', 'Yamakawa, T.'], '_pg': ['137-143'], '_kw': ['Trifluoromethylation', 'Trifluoromethyl iodide', 'Fe(II) catalyst', '5-Trifluoromethyluracil'], 'parent': {'parent': {'_jn': ['Applied Catalysis A, General'], '_t1': ['CXT0242A 0926860X'], '_cr': ['Copyright (c) 2008 Elsevier B.V.'], 'parent': {'_t0': ['CXT0242A'], '_pd': ['20080519'], '_vn': ['4.0'], 'parent': {}}}, '_t2': ['CXT0242A 0926860X 03420001'], '_is': ['1-2'], '_vl': ['342'], '_pr': ['1-158'], '_dt': ['20080630']}, '_la': ['EN'], '_t3': ['CXT0242A 0926860X 03420001 08001646'], '_ti': ['Catalytic trifluoromethylation of uracil to 5-trifluoromethyluracil by use of CF"3I and its industrial applications'], '_ab': ['The catalytic trifluoromethylation of uracil using CF"3I was investigated to find a new industrial process for the production of 5-trifluoromethyluracil. The catalytic system of FeSO"4, H"2O"2 and H"2SO"4 in dimethylsulfoxide efficiently and selectively yielded 5-trifluoromethyluracil under mild conditions. FeSO"4 exhibited the highest activity among the Fe(II) compounds tested. H"2O"2 was indispensable for the reaction and only Fe(II) compounds yielded the desired product. This characteristic of the reaction suggests that it proceeds in a Fenton oxidation manner. The reaction was applicable to large-scale production: 50kg of 5-trifluoromethyluracil in a 600L reactor. By the use of this catalytic system, selective trifluoromethylation at the 5-position was also performed with various uracil derivatives including uridines. Interestingly, Cp"2Fe was superior to FeSO"4 for several substrates.'], '_ii': ['S0926-860X(08)00164-6', '[DOI] 10.1016/j.apcata.2008.03.009'], '_ca': ['Tetsu Yamakawa. Sagami Chemical Research Center, Hayakawa 2743-1, Ayase, Kanagawa 252-1193, Japan'], '_li': ['EN'], '_mf': ['[XML Cit] 08001646']}